Attack the player unable to block Avacyn.
Worldslayer triggers on combat damage, destroying all permanents your opponent control.
Repeat each turn to prevent your opponent from accumulating permanents.

Destroy all permanents opponents control each turn

Avacyn, Angel of Hope

Worldslayer

Activate Soul of New Phyrexia by paying {5}, giving all permanents you control indestructible until end of turn.
Deal combat damage to any opponent with the creature that has Worldslayer equipped, destroying all of your opponent' permanents.

Combos with "Worldslayer"