Cast Storm King's Thunder by paying {9}{R}{R}{R}, copying the next instant or sorcery spell you cast nine times.
Cast Vraska's Fall by paying {2}{B}.
Storm King's Thunder triggers, copying Vraska's Fall nine times.
Resolve each Vraska's Fall, causing each opponent to get ten poison counters.
Each opponent loses the game due to having ten or more poison counters.

Each opponent loses the game

Storm King's Thunder

Vraska's Fall

Cast Repeated Reverberation by paying {2}{R}{R} and sacrificing a creature with power two or greater.
Repeated Reverberation's casualty ability triggers, creating two copies of it due to Twinning Staff.
Resolve each Repeated Reverberation, causing you to copy the next instant or sorcery spell you cast six times.
Cast Vraska's Fall by paying {2}{B}.
Each Repeated Reverberation triggers, copying Vraska's Fall a total of nine times due to Twinning Staff.
Resolve each Vraska's Fall, causing each opponent to get ten poison counters and sacrifice ten creatures and/or planeswalkers.
Each opponent loses the game due to having ten or more poison counters.

Anhelo, the Painter

Twinning Staff

Repeated Reverberation

Cast Howl of the Horde by paying {2}{R} and sacrificing a creature with power two or greater.
Howl of the Horde's casualty ability triggers, creating two copies of it due to Twinning Staff.
Resolve each Howl of the Horde, causing you to copy the next instant or sorcery spell you cast six times.
Cast Vraska's Fall by paying {2}{B}.
Each Howl of the Horde triggers, copying Vraska's Fall a total of nine times due to Twinning Staff.
Resolve each Vraska's Fall, causing each opponent to get ten poison counters and sacrifice ten creatures and/or planeswalkers.
Each opponent loses the game due to having ten or more poison counters.

Combos with "Vraska's Fall"