Cast Windfall by paying {2}{U}, causing each player to discard their hand and each opponent to draw cards equal to the greatest number of cards discarded this way, and you to draw twice that number due to Vnwxt.
Psychosis Crawler triggers for each card you draw, and Scrawling Crawler triggers for each card opponents draw.
Resolve the Psychosis Crawler triggers, causing each opponent to lose 1 life for each card you drew.
Resolve the Scrawling Crawler triggers, causing each opponent to lose 1 life for each card they drew.

Near-infinite lifeloss

Psychosis Crawler

Scrawling Crawler

Windfall

Vnwxt, Verbose Host

Cast Peer into the Abyss by paying {4}{B}{B}{B}, causing you to lose half your life total rounded up and draw your library due to Vnwxt.

Infinite card draw

Infinite draw triggers

Peer into the Abyss

Activate Mind Over Matter by discarding a card, tapping Rescue Leopard.
Rescue Leopard triggers, causing you to discard a card and draw four cards.
Activate Mind Over Matter by discarding a card, untapping Rescue Leopard.
Repeat.

Infinite self-discard triggers

Near-infinite card draw

Rescue Leopard

Mind Over Matter

Teferi's Ageless Insight

Activate Professor Zei's first ability by tapping it and discarding a card, causing you to draw two cards due to Vnwxt.
Activate Mind Over Matter by discarding a card, untapping Professor Zei.
Repeat.

Near-infinite looting

Professor Zei, Anthropologist

Activate a Sliver by tapping it and discarding a card, causing you to draw two cards.
Activate Mind Over Matter by discarding a card, untapping the Sliver.
Repeat.

Infinite rummaging

Hollowhead Sliver

Tap Spider-Gwen using any free method.
Spider-Gwen triggers, causing you to discard a card and draw two cards.
Activate Mind Over Matter by discarding a card, untapping Spider-Gwen.
Repeat.

Cards Allowing a Creature to Tap for Free

Spider-Gwen, Free Spirit

Activate Mind Over Matter by discarding a card, tapping Spider-Gwen.
Spider-Gwen triggers, causing you to discard a card and draw four cards.
Activate Mind Over Matter by discarding a card, untapping Spider-Gwen.
Repeat.

Thought Reflection

Activate Mindless Automaton's second ability by removing two +1/+1 counters from it, causing you to draw two cards.
The Locust God triggers twice, creating two 1/1 Insect creature tokens with flying and haste.
Activate Thermopod twice by sacrificing two Insects, adding {R}{R}.
Activate Mindless Automaton's first ability twice by paying {2} and discarding two cards, putting two +1/+1 counters on it.
Repeat.

Near-infinite ETB

Infinite looting

Near-infinite LTB

Near-infinite death triggers

Near-infinite sacrifice triggers

The Locust God

Mindless Automaton

Thermopod

Activate Zombie Infestation by discarding two cards, creating a 2/2 Zombie creature token.
Activate Umbral Collar Zealot by sacrificing the Zombie, whose power should have been altered from its base power.
When the Zombie dies, Jason Bright triggers, causing you to draw two cards.
Resolve the Umbral Collar Zealot ability.
Repeat.

Near-infinite surveil 1

Effects that Alter a Creature's Power/Toughness (Anthem Effects)

Jason Bright, Glowing Prophet

Zombie Infestation

Umbral Collar Zealot

Cast Body of Research by paying {G}{G}{G}{U}{U}{U}, creating a 0/0 Fractal creature token, then putting a number of +1/+1 counters on it equal to your eck size.
Give the Fractal token haste, if needed.
Activate Sokrates by tapping it, targeting the Fractal token.
Declare the Fractal token as an attacker, attacking an opponent unable to block it.
When the Fractal token would deal combat damage, instead prevent that damage. The defending player draws cards equal to the Fractal's power, rounded down, while you will draw double that many cards due to Vnwxt.

Combos with "Vnwxt, Verbose Host"