Cast Enter the Infinite by paying {8}{U}{U}{U}{U}, causing you to draw your entire library and then put a card from your hand on top of your library.
Declare Twenty-Toed Toad as an attacker.
Twenty-Toed Toad's second ability triggers, causing you to win the game.

Win the game

Infinite card draw

Infinite draw triggers

Twenty-Toed Toad

Enter the Infinite

Cast Peer into the Abyss by paying {4}{B}{B}{B}, causing you to draw half your library and lose half your life total, rounded up.
Declare Twenty-Toed Toad as an attacker.
Twenty-Toed Toad's second ability triggers, causing you to win the game.

Near-infinite card draw

Near-infinite draw triggers

Peer into the Abyss

Activate Resourceful Defense by paying {4}{W}, moving all charge counters from Eternity Vessel onto Twenty-Toed Toad.
Declare Twenty-Toed Toad as an attacker. It triggers, causing you to win the game.

Resourceful Defense

Eternity Vessel

Cast Star of Extinction by paying {5}{R}{R}, destroying a land, dealing 20 damage to each creature your opponents control and each planeswalker, and putting twenty +1/+1 counters on each creature you control due to Vigor.
Declare Twenty-Toed Toad as an attacker, triggering its second ability, causing you to win the game.

Combos with "Twenty-Toed Toad"