Cast Lethal Vapors by paying {2}{B}{B}.
Activate Lethal Vapors an arbitrarily large number of times.
Maintaining priority, cast Trickbind by paying {1}{U}, countering one of those triggers and preventing Lethal Vapors from being activated again until end of turn.
Cast Teferi's Protection by paying {2}{W}: until your next turn your life total can't change and you have protection from everything.
Allow all the activated abilities from Lethal Vapors to resolve, skipping an arbitrarily large number of turns.

Skip all your future turns, causing your opponents to eventually draw from an empty library and lose the game

You have protection from everything

Your life total can't change

Lock

Lethal Vapors

Teferi's Protection

Trickbind

Cast Isochron Scepter by paying {2}.
Isochron Scepter enters the battlefield, triggering its imprint ability.
Holding priority, activate Lithoform Engine's first ability by paying {2} and tapping it, copying Isochron Scepter's trigger.
Resolve both Isochron Scepter triggers, exiling Trickbind and Final Fortune from your hand.
Activate Isochron Scepter by paying {2} and tapping it, casting a copy of Final Fortune without paying its mana cost.
Resolve Final Fortune, causing you to take an extra turn after this one.
Move to your next turn.
At the beginning of the end step during your extra turn, Final Fortune triggers.
Holding prioirty, activate Isochron Scepter by paying {2} and tapping it, casting a copy of Trickbind and Final Fortune without paying their mana cost.
Resolve Trickbind, countering Final Fortune's trigger from step 8.
Repeat from step 6.

Infinite turns

Isochron Scepter

Lithoform Engine

Final Fortune

Cast Isochron Scepter by paying {2}.
Isochron Scepter enters the battlefield, triggering its imprint ability.
Holding priority, activate Tawnos by paying {U}{R} and tapping it, copying Isochron Scepter's trigger.
Resolve both Isochron Scepter triggers, exiling Trickbind and Final Fortune from your hand.
Activate Isochron Scepter by paying {2} and tapping it, casting a copy of Final Fortune without paying its mana cost.
Resolve Final Fortune, causing you to take an extra turn after this one.
Move to your next turn.
At the beginning of the end step during your extra turn, Final Fortune triggers.
Holding prioirty, activate Isochron Scepter by paying {2} and tapping it, casting a copy of Trickbind and Final Fortune without paying their mana cost.
Resolve Trickbind, countering Final Fortune's trigger from step 8.
Repeat from step 6.

Tawnos, Urza's Apprentice

Combos with "Trickbind"