At the beginning of your upkeep, Descent into Avernus triggers, putting two descent counters on it, then causing each player to create a number of Treasure tokens equal to the number of descent counters on Descent into Avernus, and causing each opponent to be dealt an amount of damage equal to the number of descent counters on Descent into Avernus.
Activate Time Sieve by tapping it and sacrificing five Treasures, causing you to take an extra turn after this one.
Repeat each turn.

Infinite turns

Lock

Time Sieve

Descent into Avernus

The Wanderer

Cast Tainted Strike by paying {B}, giving Skirk Fire Marshal +1/+0 and infect until end of turn.
Activate Skirk Fire Marshal by tapping five Goblins you control, putting ten -1/-1 counters on each creature opponents control and giving each opponent ten poison counters.
Each opponent loses the game due to having ten poison counters.

Each opponent loses the game

Skirk Fire Marshal

Tainted Strike

Cast Triumph of the Hordes by paying {2}{G}{G}, giving creatures you control +1/+1 and infect until end of turn.
Activate Skirk Fire Marshal by tapping five Goblins you control, putting ten -1/-1 counters on each creature opponents control and giving each opponent ten poison counters.
Each opponent loses the game due to having ten poison counters.

Combos with "The Wanderer"