Activate Skirge Familiar by discarding Shenanigans, adding {B}.
Bone Miser's third ability triggers, causing you to mill a card and return Shenanigans from your graveyard to your hand.
Repeat.

Infinite self-mill

Near-infinite black mana

Near-infinite self-discard triggers

Bone Miser

Shenanigans

Skirge Familiar

Attempt to draw a card. The draw will be replaced by Chains of Mephistopheles, causing you to instead discard Shenanigans. Then, you will mill a card and return Shenanigans from your graveyard to your hand due to Shenanigans's dredge ability.
Bone Miser's third ability triggers, attempting to have you draw a card. The draw will be replaced by Chains of Mephistopheles, causing you to instead discard Shenanigans. Then, you will mill a card and return Shenanigans from your graveyard to your hand due to Shenanigans's dredge ability.
Repeat step 2.

Combos with "Shenanigans"