Cast Shard of the Nightbringer by paying {5}{B}{B}{B}.
Shard of the Nightbringer triggers, causing an opponent to lose half their life total, rounded up, and you to gain life equal to the life lost this way.
Vito triggers, causing the opponent to lose life equal to the amount of life gained this way.
The opponent loses the game due to having zero or less life.

Infinite lifeloss for target opponent

Target opponent loses the game

Vito, Thorn of the Dusk Rose

Shard of the Nightbringer

Cast Shard of the Nightbringer by paying {5}{B}{B}{B}.
Shard of the Nightbringer triggers, causing an opponent to lose half their life total, rounded up, and you to gain life equal to the life lost this way.
Sanguine Bond triggers, causing the opponent to lose life equal to the amount of life gained this way.
The opponent loses the game due to having zero or less life.

Sanguine Bond

Cast Shard of the Nightbringer by paying {5}{B}{B}{B}.
When Shard of the Nightbringer enters the battlefield, it triggers, causing an opponent to lose their entire life total due to Bloodletter of Aclazotz and you to gain that much life.
The opponent loses the game due to having 0 or less life.

Near-infinite lifegain

Bloodletter of Aclazotz

Cast Shard of the Nightbringer by paying {5}{B}{B}{B}.
Shard of the Nightbringer triggers, causing an opponent to lose half their life total, rounded up, and you to gain life equal to the life lost this way.
Enduring Tenacity triggers, causing the opponent to lose life equal to the amount of life gained this way.
The opponent loses the game due to having zero or less life.

Enduring Tenacity

Cast Shard of the Nightbringer by paying {5}{B}{B}{B}.
Shard of the Nightbringer triggers, causing an opponent to lose half their life total, rounded up, and you to gain life equal to the life lost this way.
At the beginning of your end step, Wound Reflection triggers, causing each opponent to lose life equal to the life they lost this turn.
The opponent targeted in step 2 loses the game due to having zero or less life.

Wound Reflection

Cast Shard of the Nightbringer by paying {5}{B}{B}{B}.
Shard of the Nightbringer triggers, causing an opponent to lose half their life total, rounded up, and you to gain life equal to the life lost this way.
At the beginning of your end step, Archfiend of Despair triggers, causing each opponent to lose life equal to the life they lost this turn.
The opponent targeted in step 2 loses the game due to having zero or less life.

Archfiend of Despair

Cast Shard of the Nightbringer by paying {5}{B}{B}{B}.
Shard of the Nightbringer triggers, causing an opponent to lose half their life total, rounded up, and you to gain life equal to the life lost this way.
At the beginning of your end step, Warlock Class triggers, causing each opponent to lose life equal to the life they lost this turn.
The opponent targeted in step 2 loses the game due to having zero or less life.

Combos with "Shard of the Nightbringer"