Deal combat damage to an opponent with the creature that has Quietus Spike attached.
Quietus Spike triggers, causing the opponent to lose half their life total, rounded up.
At the beginning of your end step, Wound Reflection triggers, causing the opponent to lose life equal to the life they lost this turn.
The opponent loses the game due to having zero or less life.

Near-infinite lifeloss for target opponent

Target opponent loses the game

Quietus Spike

Wound Reflection

Deal combat damage to an opponent using the creature that has Quietus Spike attached.
Quietus Spike triggers, causing the defending opponent to lose their entire life total due to Bloodletter of Aclazotz.
The opponent loses the game due to having 0 or less life.

Infinite lifeloss for target opponent

Bloodletter of Aclazotz

Deal combat damage to an opponent with the creature that has Quietus Spike attached.
Quietus Spike triggers, causing the opponent to lose half their life total, rounded up.
At the beginning of your end step, Astarion triggers, causing the opponent to lose life equal to the life they lost this turn.
The opponent loses the game due to having zero or less life.

Astarion, the Decadent

Activate Goblin Sharpshooter by tapping it, dealing 1 damage to target creature.
That creature dies from lethal damage due to Goblin Sharpshooter's deathtouch ability.
Goblin Sharpshooter triggers, untapping itself.
Repeat for each creature opponents control and whenever an opponent controls a creature.

Destroy all creatures opponents control

From now on, destroy any creatures opponents control at instant speed

Goblin Sharpshooter

Deal combat damage to an opponent with the creature that has Quietus Spike attached.
Quietus Spike triggers, causing the opponent to lose half their life total, rounded up.
At the beginning of your end step, Warlock Class triggers, causing the opponent to lose life equal to the life they lost this turn.
The opponent loses the game due to having zero or less life.

Warlock Class

Deal combat damage to an opponent with the creature that has Quietus Spike attached.
Quietus Spike triggers, causing the opponent to lose half their life total, rounded up.
At the beginning of your end step, Archfiend of Despair triggers, causing the opponent to lose life equal to the life they lost this turn.
The opponent loses the game due to having zero or less life.

Archfiend of Despair

Deal combat damage to an opponent with the creature that has Quietus Spike attached.
Quietus Spike triggers, causing the opponent to lose half their life total, rounded up.
At the beginning of your end step, Blitzwing triggers, causing the opponent to lose life equal to the life they lost this turn.
The opponent loses the game due to having zero or less life.

Blitzwing, Cruel Tormentor // Blitzwing, Adaptive Assailant

Activate Deathbringer Thoctar by removing a +1/+1 counter from it, dealing 1 damage to any creature an opponent controls.
The creature dies as a state-based action due to Deathbringer Thoctar's deathtouch.
Deathbringer Thoctar triggers, putting a +1/+1 counter on itself.
Repeat as desired.
You may also repeat this combo whenever a creature enters the battlefield under an opponent's control.

Destroy any creature that enters the battlefield under an opponent's control

Deathbringer Thoctar

Activate the creature by tapping it, dealing damage to an opponent's creature.
The opponent's creature dies due to deathtouch, triggering the second ability granted by Thornbite Staff, untapping your creature.
Repeat until all opponents' creatures die.
Repeat each time a creature enters the battlefield under an opponent's control.

Destroy all creatures opponents control whenever a creature enters the battlefield

Thornbite Staff

Viridian Longbow

Activate Eater of the Dead by tapping it, dealing 1 damage to any nontoken creature an opponent controls.
The creature dies due to Eater of the Dead's deathtouch.
Activate Eater of the Dead by paying {0}, exiling the creature card from its owner's graveyard  and untapping Eater of the Dead.
Repeat.
You may also repeat this loop whenever a creature enters the battlefield under an opponent's control.

Combos with "Quietus Spike"