Cast Prologue to Phyresis by paying {1}{U}, causing each opponent to get a poison counter and you to draw a card.
Cast Expansion Algorithm by paying {9}{U}{U}, proliferating nine times and causing each opponent to get nine poison counters.
Each opponent loses the game due to having ten poison counters.

Win the game

Prologue to Phyresis

Expansion Algorithm

Cast Storm King's Thunder by paying {9}{R}{R}{R}, copying the next instant or sorcery spell you cast nine times.
Cast Prologue to Phyresis by paying {1}{U}.
Storm King's Thunder triggers, copying Prologue to Phyresis nine times.
Resolve each Prologue to Phyresis, causing each opponent to get ten poison counters and you to draw ten cards.
Each opponent loses the game due to having ten or more poison counters.

Each opponent loses the game

Storm King's Thunder

Cast Repeated Reverberation by paying {2}{R}{R} and sacrificing a creature with power two or greater.
Repeated Reverberation's casualty ability triggers, creating two copies of it due to Twinning Staff.
Resolve each Repeated Reverberation, causing you to copy the next instant or sorcery spell you cast six times.
Cast Prologue to Phyresis by paying {1}{U}.
Each Repeated Reverberation triggers, copying Prologue to Phyresis a total of nine times due to Twinning Staff.
Resolve each Prologue to Phyresis, causing each opponent to get ten poison counters, and you to draw ten cards.
Each opponent loses the game due to having ten or more poison counters.

Anhelo, the Painter

Twinning Staff

Repeated Reverberation

Cast Howl of the Horde by paying {2}{R} and sacrificing a creature with power two or greater.
Howl of the Horde's casualty ability triggers, creating two copies of it due to Twinning Staff.
Resolve each Howl of the Horde, causing you to copy the next instant or sorcery spell you cast six times.
Cast Prologue to Phyresis by paying {1}{U}.
Each Howl of the Horde triggers, copying Prologue to Phyresis a total of nine times due to Twinning Staff.
Resolve each Prologue to Phyresis, causing each opponent to get ten poison counters, and you to draw ten cards.
Each opponent loses the game due to having ten or more poison counters.

Combos with "Prologue to Phyresis"