Cast Beacon of Immortality by paying {5}{W}, causing target opponent to lose life equal to their life total due to Plague Drone.
The opponent loses the game due to having zero life.

Infinite lifeloss for target opponent

Target opponent loses the game

Beacon of Immortality

Plague Drone

Cast Magister Sphinx by paying {4}{W}{U}{B}.
Magister Sphinx enters the battlefield, causing target opponent's life total to become 10.
Cast Aria of Flame by paying {2}{R}.
Aria of Flame enters the battlefield, causing each opponent to lose 10 life due to Plague Drone.
The opponent who was targeted in step 2 loses the game due to having zero life.

Combos with "Plague Drone"