Cast Fire Covenant by paying {1}{B}{R} and an amount of life equal to your life total minus 1, targeting any creature.
Judith triggers, giving Fire Covenant deathtouch and lifelink.
Resolve Fire Covenant, dealing damage equal to the life paid to the targeted creature and causing you to gain that much life.
Vito triggers, dealing that much damage to target opponent.

Near-infinite lifeloss for target opponent

Judith, Carnage Connoisseur

Vito, Thorn of the Dusk Rose

Fire Covenant

Cast Fire Covenant by paying {1}{B}{R} and an amount of life equal to your life total minus 1, targeting any creature.
Judith triggers, giving Fire Covenant deathtouch and lifelink.
Resolve Fire Covenant, dealing damage equal to the life paid to the targeted creature and causing you to gain that much life.
Sanguine Bond triggers, dealing that much damage to target opponent.

Sanguine Bond

Cast Wheel of Misfortune by paying {2}{R}.
Judith triggers, giving Wheel of Misfortune deathtouch and lifelink.
Resolve Wheel of Misfortune, choosing an arbitrarily large number.
If you didn't choose the largest number, Wheel of Misfortune deals damage equal to the highest number chosen to each player that chose it, causing those players to lose the game due to having 0 or less life.
If you chose the largest number, Wheel of Misfortune deals that much damage to you and causes you to gain that much life.
Vito triggers, causing an opponent to lose lfie equal to the life you gained.
The opponent loses the game due to having 0 or less life.

Wheel of Misfortune

Cast Wheel of Misfortune by paying {2}{R}.
Judith triggers, giving Wheel of Misfortune deathtouch and lifelink.
Resolve Wheel of Misfortune, choosing an arbitrarily large number.
If you didn't choose the largest number, Wheel of Misfortune deals damage equal to the highest number chosen to each player that chose it, causing those players to lose the game due to having 0 or less life.
If you chose the largest number, Wheel of Misfortune deals that much damage to you and causes you to gain that much life.
Sanguine Bond triggers, causing an opponent to lose lfie equal to the life you gained.
The opponent loses the game due to having 0 or less life.

Cast Fire Covenant by paying {1}{B}{R} and an amount of life equal to your life total minus 1, targeting any creature.
Judith triggers, giving Fire Covenant deathtouch and lifelink.
Resolve Fire Covenant, dealing damage equal to the life paid to the targeted creature and causing you to gain that much life.
Enduring Tenacity triggers, dealing that much damage to target opponent.

Enduring Tenacity

Cast Wheel of Misfortune by paying {2}{R}.
Judith triggers, giving Wheel of Misfortune deathtouch and lifelink.
Resolve Wheel of Misfortune, choosing an arbitrarily large number.
If you didn't choose the largest number, Wheel of Misfortune deals damage equal to the highest number chosen to each player that chose it, causing those players to lose the game due to having 0 or less life.
If you chose the largest number, Wheel of Misfortune deals that much damage to you and causes you to gain that much life.
Enduring Tenacity triggers, causing an opponent to lose lfie equal to the life you gained.
The opponent loses the game due to having 0 or less life.

Cast Wheel of Misfortune by paying {2}{R}.
Judith triggers, giving Wheel of Misfortune deathtouch and lifelink.
Resolve Wheel of Misfortune, choosing an arbitrarily large number.
If you didn't choose the largest number, Wheel of Misfortune deals damage equal to the highest number chosen to each player that chose it, causing those players to lose the game due to having 0 or less life.
If you chose the largest number, Wheel of Misfortune deals that much damage to you and causes you to gain twice that much life.

Near-infinite lifegain

Alhammarret's Archive

Cast Searing Touch with buyback by paying {R}. Storm-Kiln Artist, Blood Funnel and Judith trigger.
Storm-Kiln Artist triggers, creating a Treasure token.
Activate the Treasure by tapping and sacrificing it, adding {R}.
Resolve the Judith trigger, creating a 2/2 Imp creature token.
Resolve the Blood Funnel trigger, causing you to sacrifice the Imp.
When the Imp dies, it triggers, dealing 2 damage to each opponent.
Resolve the Searing Touch spell.
Repeat.

Combos with "Judith, Carnage Connoisseur"