Activate Automated Assembly Line by paying {E}{E}{E}, creating a 3/3 Robot artifact creature token.
When the Robot enters the battlefield, Gonti's Aether Heart triggers, causing you to get {E}{E}{E}.
Repeat.

Infinite creature tokens

Infinite ETB

Automated Assembly Line

Gonti's Aether Heart

Izzet Generatorium

Activate Whirler Virtuoso by paying {E}{E}{E}, creating a 1/1 Thopter artifact creature token.
When the Thopter enters the battlefield, Guide of Souls triggers, causing you to get {E}{E}{E} and gain 1 life.
Repeat.

Infinite lifegain triggers

Infinite lifegain

Infinite energy counters

Whirler Virtuoso

Guide of Souls

Aether Refinery

Activate Whirler Virtuoso by paying {E}{E}{E}, creating a 1/1 Thopter artifact creature token.
When the Thopter enters the battlefield, Guide of Souls triggers, causing you to get {E}{E} and gain 1 life.
Sphinx of the Revelation triggers, causing you to get {E}{E}.
Repeat.

Sphinx of the Revelation

Activate Aethergeode Miner by paying {E}{E}, blinking it.
When Aethergeode Miner enters the battlefield, Decoction Module triggers, causing you to get {E}{E}.
Repeat.

Infinite LTB

Aethergeode Miner

Decoction Module

Activate Aethergeode Miner by paying {E}{E}, blinking it.
When Aethergeode Miner enters the battlefield, Aetherstorm Roc triggers, causing you to get {E}{E}.
Repeat.

Aetherstorm Roc

Activate Automated Assembly Line by paying {E}{E}{E}, creating a 3/3 Robot artifact creature token.
When the Robot enters the battlefield, Guide of Souls triggers, causing you to get {E}{E} and gain 1 life.
Sphinx of the Revelation triggers, causing you to get {E}{E}.
Repeat.

Activate Aethergeode Miner by paying {E}{E}, blinking it.
When Aethergeode Miner enters the battlefield, Guide of Souls triggers, causing you to get {E}{E} and gain 1 life.
Repeat.

Activate Izzet Generatorium by tapping it, causing you to draw a card.
Activate Mind Over Matter by discarding a card, untapping Izzet Generatorium.
Repeat.

Infinite draw triggers

Infinite looting

Infinite self-discard triggers

Mind Over Matter

Cast Ugin's Nexus by paying {5}.
Saheeli's first ability triggers, causing you to get {E}{E}{E}{E}.
At the beginning of your combat phase, Saheeli's second ability triggers, causing you to pay {E}{E}{E} to create a token copy of Ugin's Nexus that is a 5/5 artifact creature.
Put the nontoken Ugin's Nexus into exile due to the legend rule and its replacement effect, causing you to take an extra turn after this one.
Activate Karn's first loyalty ability by putting two loyalty counters on it.
At the beginning of the end step, Saheeli triggers, causing you to sacrifice the Ugin's Nexus token. The token put into exile due to its replacement effect, causing you to take an extra turn after this one.
Move to your first extra turn.
Activate Karn's second loyalty ability ability by removing two loyalty counters from it, putting Ugin's Nexus into your hand from exile.
Move to your second extra turn, and repeat from step 1.

Infinite turns

Saheeli, Radiant Creator

Karn, the Great Creator

Ugin's Nexus

Cast Rite of Replication with kicker by paying {7}{U}{U}, creating five token copies of Aetherstorm Roc.
When the Aetherstorm Roc tokens enter the battlefield, each Aetherstorm Roc you control triggers five times, causing you to get 60 {E}.
Activate Architect of the Untamed by paying eight {E}, creating a 6/6 Beast artifact creature token.
When the Beast enters the battlefield, each Aetherstorm Roc you control triggers, causing you to get twelve {E}.
Repeat from step 3.

Combos with "Izzet Generatorium"