Cast Storm King's Thunder by paying {9}{R}{R}{R}, copying the next instant or sorcery spell you cast nine times.
Cast Infectious Inquiry by paying {2}{B}.
Storm King's Thunder triggers, copying Infectious Inquiry nine times.
Resolve each Infectious Inquiry, causing each opponent to get ten poison counters, and you to lose twenty life and draw twenty cards.
Each opponent loses the game due to having ten or more poison counters.

Each opponent loses the game

Storm King's Thunder

Infectious Inquiry

Cast Repeated Reverberation by paying {2}{R}{R} and sacrificing a creature with power two or greater.
Repeated Reverberation's casualty ability triggers, creating two copies of it due to Twinning Staff.
Resolve each Repeated Reverberation, causing you to copy the next instant or sorcery spell you cast six times.
Cast Infectious Inquiry by paying {2}{B}.
Each Repeated Reverberation triggers, copying Infectious Inquiry a total of nine times due to Twinning Staff.
Resolve each Infectious Inquiry, causing each opponent to get ten poison counters, and causing you to lose twenty life and draw twenty cards.
Each opponent loses the game due to having ten or more poison counters.

Anhelo, the Painter

Twinning Staff

Repeated Reverberation

Cast Howl of the Horde by paying {2}{R} and sacrificing a creature with power two or greater.
Howl of the Horde's casualty ability triggers, creating two copies of it due to Twinning Staff.
Resolve each Howl of the Horde, causing you to copy the next instant or sorcery spell you cast six times.
Cast Infectious Inquiry by paying {2}{B}.
Each Howl of the Horde triggers, copying Infectious Inquiry a total of nine times due to Twinning Staff.
Resolve each Infectious Inquiry, causing each opponent to get ten poison counters, and causing you to lose twenty life and draw twenty cards.
Each opponent loses the game due to having ten or more poison counters.

Combos with "Infectious Inquiry"