Cast Fraying Omnipotence by paying {3}{B}{B}, causing each player to lose half their life, then discard half the cards in their hand, then sacrifice half the creatures they control, rounding up each time.
At the beginning of your end step, Wound Reflection triggers, causing each opponent to lose life equal to the life they have lost this turn.
Each opponent loses the game due to having zero or less life.

Each opponent loses the game

Near-infinite lifeloss

Fraying Omnipotence

Wound Reflection

Cast Fraying Omnipotence by paying {3}{B}{B}, causing each opponent to lose their entire life total due to Bloodletter of Aclazotz, you to lose half your life total, and then causing each player to discard half their hand and sacrifice half the creatures they control.
Each opponent loses the game due to having 0 or less life.

Infinite lifeloss

Bloodletter of Aclazotz

Cast Fraying Omnipotence by paying {3}{B}{B}, causing each player to lose life equal to half their life total, discard half their hand, and sacrifice half of the creatures they control, rounding up each time.
At the beginning of your end step, Astarion triggers, causing an opponent to lose life equal to the life they lost this turn.
The opponent loses the game due to having zero or less life.

Target opponent loses the game

Astarion, the Decadent

Cast Fraying Omnipotence by paying {3}{B}{B}, causing each player to lose half their life, then discard half the cards in their hand, then sacrifice half the creatures they control, rounding up each time.
At the beginning of your end step, Warlock Class triggers, causing each opponent to lose life equal to the life they have lost this turn.

Warlock Class

Cast Fraying Omnipotence by paying {3}{B}{B}, causing each player to lose half their life, then discard half the cards in their hand, then sacrifice half the creatures they control, rounding up each time.
At the beginning of your end step, Archfiend of Despair triggers, causing each opponent to lose life equal to the life they have lost this turn.

Archfiend of Despair

Cast Fraying Omnipotence by paying {3}{B}{B}, causing each player to lose life equal to half their life total, discard half their hand, and sacrifice half of the creatures they control, rounding up each time.
At the beginning of your end step, Blitzwing triggers, causing an opponent to lose life equal to the life they lost this turn.
The opponent loses the game due to having zero or less life.

Combos with "Fraying Omnipotence"