Gain life.
Sanguine Bond triggers, causing an opponent to lose 1 life.
Exquisite Blood triggers, causing you to gain 1 life.
Repeat from step 2.

Infinite lifegain triggers

Infinite lifeloss

Infinite lifegain

Exquisite Blood

Sanguine Bond

Activate Aetherflux Reservoir by paying 50 life, dealing 50 damage to target opponent.
Exquisite Blood triggers, causing you to gain you 50 life.
Repeat.

Infinite damage

Aetherflux Reservoir

Draw a card.
Psychosis Crawler triggers, causing each opponent to lose 1 life.
Exquisite Blood triggers for each opponent.
Resolve the first Exquisite Blood trigger, causing you to gain 1 life.
Drogskol Reaver triggers, causing you to draw a card.
Repeat from step 2.

Infinite card draw

Infinite draw triggers

Near-infinite lifegain

Near-infinite lifegain triggers

Near-infinite lifeloss

Near-infinitely large Psychosis Crawler

Psychosis Crawler

Drogskol Reaver

Activate Ashnod's Altar by sacrificing a creature token, adding {C}{C}.
Mirkwood Bats triggers, causing each opponent to lose 1 life.
Exquisite Blood triggers for each opponent.
Resolve the first trigger, causing you to gain 1 life.
Trudge Garden triggers, causing you to pay {2} to create a 4/4 Fungus Beast creature token.
Mirkwood Bats triggers, causing each opponent to lose 1 life.
Exquisite Blood triggers for each opponent.
Holding priority, repeat from step 1.
Resolve all remaining Exquisite Blood triggers, causing you to gain that much life, choosing not to pay for the Trudge Garden triggers in between.

Infinite death triggers

Infinite ETB

Infinite LTB

Infinite sacrifice triggers

Trudge Garden

Ashnod's Altar

Mirkwood Bats

Draw a card.
Niv-Mizzet triggers, dealing 1 damage to an opponent.
Exquisite Blood triggers, causing you to gain 1 life.
Lich's Mastery triggers, causing you to draw a card.
Repeat from step 2.

Near-infinite damage

Niv-Mizzet, Parun

Lich's Mastery

Draw a card.
Niv-Mizzet triggers, dealing 1 damage to an opponent.
Exquisite Blood triggers, causing you to gain 1 life.
Marina Vendrell's Grimoire triggers, causing you to draw a card.
Repeat from step 2.

Niv-Mizzet, the Firemind

Marina Vendrell's Grimoire

Combos with "Exquisite Blood"