Cast Harmless Offering by paying {2}{R}, giving an opponent control of Nefarious Lich.
Activate Despotic Scepter by tapping it, destroying Nefarious Lich.
When Nefarious Lich leaves the battlefield, it triggers, causing its controller to lose the game.

Target opponent loses the game

Despotic Scepter

Nefarious Lich

Harmless Offering

Cast Donate by paying {2}{U}, giving an opponent control of Nefarious Lich.
Activate Despotic Scepter by tapping it, destroying Nefarious Lich.
When Nefarious Lich leaves the battlefield, it triggers, causing its controller to lose the game.

Donate

Cast Role Reversal by paying {U}{U}{R}, exchanging control of an enchantment an opponent controls and Nefarious Lich.
Activate Despotic Scepter by tapping it, destroying Nefarious Lich.
When Nefarious Lich leaves the battlefield, it triggers, causing its controller to lose the game.

Role Reversal

Activate Zedruu by paying {U}{R}{W}, giving an opponent control of Nefarious Lich.
Activate Despotic Scepter by tapping it, destroying Nefarious Lich.
When Nefarious Lich leaves the battlefield, it triggers, causing its controller to lose the game.

Combos with "Despotic Scepter"