Cast the red permanent card in your hand by paying 2 life.
Defiler of Instinct and Aetherflux Reservoir triggers.
Resolve the Defiler of Instinct trigger, dealing 1 damage to any target.
Resolve the Aetherflux Reservoir trigger, causing you to gain 1 life for each spell you've cast before it this turn.
The red permanent enters the battlefield, triggering Cloudstone Curio, returning another nontoken nonartifact red permanent with mana cost {R} from the battlefield to your hand.
Repeat.

Infinite creature tokens

Infinite damage

Infinite creature ETB

Infinite lifegain

Infinite lifegain triggers

Infinite creature LTB

Infinite storm count

Aetherflux Reservoir

Cloudstone Curio

Defiler of Instinct

Activate Grinning Ignus by paying {R} and returning it to your hand from the battlefield, adding {C}{C}{R}.
Cast Grinning Ignus by paying {2} and 2 life.
Defiler of Instinct triggers, dealing 1 damage to any target.
When Grinning Ignus enters the battlefield, Healer of the Pride triggers, causing you to gain 2 life.
Repeat.

Grinning Ignus

Healer of the Pride

Activate Faith Healer by sacrificing Fiery Mantle.
When Fiery Mantle leaves the battlefield, it triggers, returning itself to your hand from your graveyard.
Resolve the Faith Healer ability, causing you to gain two life.
Cast Fiery Mantle by paying two life, targeting any creature you control.
Defiler of Instinct triggers, dealing 1 damage to any target.
Repeat.

Fiery Mantle

Faith Healer

Danitha Capashen, Paragon

Starnheim Courser

Cloud Key

Activate Faith Healer by sacrificing Fiery Mantle.
When Fiery Mantle leaves the battlefield, it triggers, returning itself to your hand from your graveyard.
Resolve the Faith Healer ability, causing you to gain two life.
Cast Fiery Mantle by paying two life, targeting Hero of Iroas.
Defiler of Instinct and Hero of Iroas trigger.
Resolve the Defier of Instinct trigger, dealing 1 damage to any target.
Resolve the Hero of Iroas trigger, putitng a +1/+1 counter on it.
Repeat.

Infinite +1/+1 counters on a creature

Hero of Iroas

Cast Dargo from the command zone by paying two life.
Defiler of Instinct and Aetherflux Reservoir trigger.
Resolve the Defiler of Instinct trigger,  dealing 1 damage to any target.
Resolve the Aetherflux Reservoir trigger, causing you to gain 1 life for each spell you've cast this turn.
Activate Razaketh by paying two life and sacrificing Dargo.
Choose to return Dargo to the command zone from your graveyard.
Resolve the Razaketh ability, causing you to search your library for a card and put it into your hand.
Repeat.

Combos with "Defiler of Instinct"