Cast Acererak by paying 2 life.
Bontu's Monument and Defiler of Faith trigger.
Resolve the Bontu's Monument trigger, losing each opponent 1 life and gaining you 1 life.
Resolve the Defiler of Faith trigger, giving a creature you control +1/+1 until end of turn.
Acererak enters the battlefield, triggering Ayara and itself.
Resolve the Ayara trigger, losing each opponent 1 life and gaining you 1 life.
Resolve Acererak trigger, returning it to your hand and venturing into the Lost Mine of Phandelver.
Each time you trigger the Dark Pool room ability, each opponent loses 1 life and you gain 1 life.
Repeat.

Infinite card draw

Infinite draw triggers

Near-infinite +1/+1 counters

Near-infinite ETB

Near-infinite LTB

Near-infinite Treasure tokens

Near-infinite colored mana

Near-infinite creature tokens

Near-infinite lifegain

Near-infinite lifegain triggers

Near-infinite lifeloss

Near-infinite storm count

Near-infinite ventures into the dungeon

Near-infinitely large creatures you control until end of turn

Acererak the Archlich

Ayara, First of Locthwain

Bontu's Monument

Defiler of Flesh

Jet Medallion

Activate Ashnod's Altar by sacrificing Gravecrawler, adding {C}{C}.
Cast Gravecrawler from your graveyard by paying 2 life.
Aetherflux Reservoir and Defiler of Flesh trigger.
Resolve the Aetherflux Reservoir trigger, causing you to gain 1 life for each spell you've cast this turn.
Resolve the Defiler of Flesh trigger, giving target creature +1/+1 and menace until end of turn.
Repeat.
Once you have infinite life, you may activate Aetherflux Reservoir's ability to deal infinite damage to any target(s).

Infinite colorless mana

Infinite damage

Infinite death triggers

Infinite ETB

Infinite lifegain

Infinite lifegain triggers

Infinite LTB

Infinitely large creatures you control until end of turn

Infinite sacrifice triggers

Infinite storm count

Aetherflux Reservoir

Gravecrawler

Ashnod's Altar

Activate Carrion Feeder by sacrificing Gravecrawler, putting a +1/+1 counter on Carrion Feeder.
Cast Gravecrawler from your graveyard by paying 2 life.
Aetherflux Reservoir and Defiler of Flesh trigger.
Resolve the Aetherflux Reservoir trigger, causing you to gain 1 life for each spell you've cast this turn.
Resolve the Defiler of Flesh trigger, giving target creature +1/+1 and menace until end of turn.
Repeat.
Once you have infinite life, you may activate Aetherflux Reservoir's ability to deal infinite damage to any target(s).

Infinite +1/+1 counters on a creature

Carrion Feeder

Activate Viscera Seer by sacrificing Gravecrawler, causing you to scry 1.
Cast Gravecrawler from your graveyard by paying 2 life.
Aetherflux Reservoir and Defiler of Flesh trigger.
Resolve the Aetherflux Reservoir trigger, causing you to gain 1 life for each spell you've cast this turn.
Resolve the Defiler of Flesh trigger, giving target creature +1/+1 and menace until end of turn.
Repeat.
Once you have infinite life, you may activate Aetherflux Reservoir's ability to deal infinite damage to any target(s).

Infinite scry 1

Viscera Seer

Cast the black permanent card in your hand by paying 2 life.
Defiler of Flesh and Aetherflux Reservoir triggers.
Resolve the Defiler of Flesh trigger, giving target creature +1/+1 and menace until end of turn.
Resolve the Aetherflux Reservoir trigger, causing you to gain 1 life for each spell you've cast before it this turn.
The black permanent enters the battlefield, triggering Cloudstone Curio, returning another nontoken nonartifact black permanent with mana cost {B} from the battlefield to your hand.
Repeat.
Once you have infinite life, you may activate Aetherflux Reservoir infinite times to deal infinite damage to any target(s).

Infinite creature tokens

Cloudstone Curio

Activate Altar of Dementia by sacrificing Gravecrawler, causing target player to mill cards equal to Gravecrawler's power.
Cast Gravecrawler from your graveyard by paying 2 life.
Aetherflux Reservoir and Defiler of Flesh trigger.
Resolve the Aetherflux Reservoir trigger, causing you to gain 1 life for each spell you've cast this turn.
Resolve the Defiler of Flesh trigger, giving target creature +1/+1 and menace until end of turn.
Repeat.
Once you have infinite life, you may activate Aetherflux Reservoir's ability to deal infinite damage to any target(s).

Infinite mill

Infinite self-mill

Altar of Dementia

Combos with "Defiler of Flesh"