Activate Heartless Hidetsugu by tapping it, causing it to deal damage to the opponent enchanted by Curse of Bloodletting equal to the opponent's life total, and to each other player equal to half their life total, rounded down.
The opponent enchanted by Curse of Bloodletting loses the game due to having zero or less life.

Near-infinite damage

Target opponent loses the game

Heartless Hidetsugu

Curse of Bloodletting

Activate Aetherflux Resevoir by paying fifty life, targeting yourself and causing you to gain 100 life due to Purity and Curse of Bloodletting.
Repeat an arbitrarily large number of times.
Activate Aetherflux Resevoir by paying fifty life, dealing fifty damage to any target.
Repeat step 3.

Combos with "Curse of Bloodletting"