Cast Blood Tribute with kicker by paying {4}{B}{B} and tapping Vito, causing an opponent to lose half their life total rounded up and you to gain the much life.
Vito triggers, causing the opponent to lose life equal to the life you gained.
The opponent loses the game due to having 0 or less life.

Target opponent loses the game

Infinite lifeloss for target opponent

Vito, Thorn of the Dusk Rose

Blood Tribute

Cast Blood Tribute by paying {4}{B}{B}, causing an opponent to lose their entire life total due to Bloodletter of Aclazotz.
The opponent loses the game due to having 0 or less life.
You may optionally pay Blood Tribute's kicker cost if you control an untapped Vampire to gain life equal to the chosen opponent's life total.

Near-infinite lifegain

Bloodletter of Aclazotz

Cast Blood Tribute by paying {4}{B}{B} and optionally choosing to tap a Vampire, causing an opponent to lose half their life total, rounded up, and causing you to gain life equal to the life lost this way if you paid the kicker cost.
At the beginning of your end step, Astarion triggers, causing an opponent to lose life equal to the life they lost this turn.
The opponent loses the game due to having 0 or less life.

Astarion, the Decadent

Activate Zevlor by paying {2} and tapping it, causing you to copy the next spell you cast this turn that targets a single opponent for each other opponent.
Cast Blood Tribute with kicker by paying {4}{B}{B} and tapping a Vampire you control, targeting any opponent.
Zevlor triggers, copying Peer into the Abyss for each opponent.
Resolve each Peer into the Abyss, causing each opponent to lose half their life total, rounded up, and you to gain life equal to the life lost this way.
At the beginning of your end step, Wound Reflection triggers, causing each opponent to lose life equal to the life they lost this turn.
Each opponent loses the game due to having zero or less life.

Each opponent loses the game

Near-infinite lifeloss

Zevlor, Elturel Exile

Wound Reflection

Activate Zevlor by paying {2} and tapping it, causing you to copy the next spell you cast this turn that targets a single opponent for each other opponent.
Cast Blood Tribute with kicker by paying {4}{B}{B} and tapping a Vampire you control, targeting any opponent.
Zevlor triggers, copying Peer into the Abyss for each opponent.
Resolve each Peer into the Abyss, causing each opponent to lose half their life total, rounded up, and you to gain life equal to the life lost this way.
At the beginning of your end step, Archfiend of Despair triggers, causing each opponent to lose life equal to the life they lost this turn.
Each opponent loses the game due to having zero or less life.

Archfiend of Despair

Activate Zevlor by paying {2} and tapping it, causing you to copy the next spell you cast this turn that targets a single opponent for each other opponent.
Cast Blood Tribute with kicker by paying {4}{B}{B} and tapping a Vampire you control, targeting any opponent.
Zevlor triggers, copying Peer into the Abyss for each opponent.
Resolve each Peer into the Abyss, causing each opponent to lose half their life total, rounded up, and you to gain life equal to the life lost this way.
At the beginning of your end step, Warlock Class triggers, causing each opponent to lose life equal to the life they lost this turn.
Each opponent loses the game due to having zero or less life.

Combos with "Blood Tribute"