Activate Goblin Sharpshooter by tapping it, dealing 1 damage to target creature.
That creature dies from lethal damage due to Goblin Sharpshooter's deathtouch ability.
Goblin Sharpshooter triggers, untapping itself.
Repeat for each creature opponents control and whenever an opponent controls a creature.

Destroy all creatures opponents control

From now on, destroy any creatures opponents control at instant speed

Lock

Goblin Sharpshooter

Basilisk Collar

Activate Deathbringer Thoctar by removing a +1/+1 counter from it, dealing 1 damage to any creature an opponent controls and causing you to gain 1 life.
The creature dies as a state-based action due to Deathbringer Thoctar's deathtouch.
Deathbringer Thoctar triggers, putting a +1/+1 counter on itself.
Repeat as desired.
You may also repeat this combo whenever a creature enters the battlefield under an opponent's control.

Destroy each creature that enters the battlefield under an opponent's control

Deathbringer Thoctar

Activate the creature by tapping it, dealing damage to an opponent's creature.
The opponent's creature dies due to deathtouch, triggering the second ability granted by Thornbite Staff, untapping your creature.
Repeat until all opponents' creatures die.
Repeat each time a creature enters the battlefield under an opponent's control.

Destroy all creatures opponents control whenever a creature enters the battlefield

Thornbite Staff

Viridian Longbow

At the beginning of your combat phase, Captain Rex Nebula triggers, causing Aetherflux Reservoir to become a Vehicle artifact with crew 2.
Activate Aetherflux Reservoir's crew ability by tapping Captain Rex Nebula, causing Aetherflux Reservoir to become an artifact creature until end of turn.
Give Aetherflux Reservoir lifelink.
Activate Aetherflux Reservoir by paying 50 life, dealing 50 damage to any target and causing you to gain 50 life.
Aetherflux Reservoir triggers.
Holding priority, repeat from step 4.

Infinite lifegain triggers

Infinite damage

Infinite die rolls

Captain Rex Nebula

Aetherflux Reservoir

Activate Eater of the Dead by tapping it, dealing 1 damage to any nontoken creature an opponent controls.
The creature dies due to Eater of the Dead's deathtouch.
Activate Eater of the Dead by paying {0}, exiling the creature card from its owner's graveyard  and untapping Eater of the Dead.
Repeat.
You may also repeat this loop whenever a creature enters the battlefield under an opponent's control.

Destroy any number of creatures opponents control

Eater of the Dead

Activate Phyrexian Colossus by tapping it, dealing 8 damage to any target and causing you to gain eight life.
Activate Phyrexian Colossus by paying eight life, untapping it.
Repeat.

Phyrexian Colossus

Burning Anger

Activate Famished Paladin by tapping it, dealing 1 damage to an opponent and causing you to draw a card and gain 1 life.
Famished Paladin triggers, untapping itself.
Repeat.

Infinite card draw

Infinite draw triggers

Near-infinite damage

Near-infinite lifegain

Near-infinite lifegain triggers

Famished Paladin

Quicksilver Dagger

Activate Lurking Roper by tapping it, dealing 1 damage to an opponent and causing you to draw a card and gain 1 life.
Lurking Roper triggers, untapping itself.
Repeat.

Lurking Roper

Place a counter on a permanent or player.
All Will Be One triggers, dealing 1 damage to an opponent and causing you to gain 1 life.
Vraska triggers, putting a +1/+1 counter on All Will Be One.
Repeat from step 2.

Combos with "Basilisk Collar"