Cast Magister Sphinx by paying {4}{W}{U}{B}.
Magister Sphinx enters the battlefield, causing target opponent's life total to become 10.
Cast Aria of Flame by paying {2}{R}.
Aria of Flame enters the battlefield, causing each opponent to lose 10 life due to Plague Drone.
The opponent who was targeted in step 2 loses the game due to having zero life.

Infinite lifeloss for target opponent

Target opponent loses the game

Magister Sphinx

Aria of Flame

Plague Drone

Cast Magister Sphinx by paying {4}{W}{U}{B}.
Magister Sphinx enters the battlefield, causing target opponent's life total to become ten.
Cast Aria of Flame by paying {2}{R}.
Aria of Flame enters the battlefield, causing each opponent to lose ten life.
The opponent whose life total was set in step 2 loses the game due to having zero or less life.

Combos with "Aria of Flame"