Activate Automated Assembly Line by paying {E}{E}{E}, creating a 3/3 Robot artifact creature token.
When the Robot enters the battlefield, Gonti's Aether Heart triggers, causing you to get {E}{E}{E}{E}.
Repeat.

Infinite creature tokens

Infinite energy counters

Infinite creature ETB

Automated Assembly Line

Gonti's Aether Heart

Aether Refinery

Activate Whirler Virtuoso by paying {E}{E}{E}, creating a 1/1 Thopter artifact creature token.
When the Thopter enters the battlefield, Guide of Souls triggers, causing you to get {E}{E}{E} and gain 1 life.
Repeat.

Infinite lifegain triggers

Infinite lifegain

Whirler Virtuoso

Guide of Souls

Izzet Generatorium

Activate Whirler Virtuoso by paying {E}{E}{E}, creating a 1/1 Thopter artifact creature token.
When the Thopter enters the battlefield, Guide of Souls triggers, causing you to get {E}{E} and gain 1 life.
Sphinx of the Revelation triggers, causing you to get {E}{E}.
Repeat.

Sphinx of the Revelation

Activate Automated Assembly Line by paying {E}{E}{E}, creating a 3/3 Robot artifact creature token.
When the Robot enters the battlefield, Guide of Souls triggers, causing you to get {E}{E} and gain 1 life.
Sphinx of the Revelation triggers, causing you to get {E}{E}.
Repeat.

Cast Aethertide Whale by paying eight {E} if able or {4}{U}{U} otherwise.
When Aethertide Whale enters the battlefield, it triggers, causing you to get twelve {E}.
Activate Aethertide Whale by paying {E}{E}{E}{E}, returning it from the battlefield to your hand.
Repeat.

Infinite creature LTB

Infinite storm count

Aethertide Whale

Nissa, Worldsoul Speaker

At the beginning of your combat phase, Saheeli triggers, causing you to pay {E}{E}{E} to create a token copy of Aethertide Whale with haste.
When the Aethertide Whale token enters the battlefield, it triggers, causing you to get twelve {E}.
Declare Lightning Runner as an attacker, triggering its ability, causing you to get {E}{E}{E}{E} and then pay eight {E} to untap all creatures you control and to get an additional combat phase after this one.
Repeat each combat phase.

Infinite creature sacrifice triggers

Infinite death triggers

Infinite combat phases

Infinite creature tokens with haste

Infinite untap of creatures you control

Infinite mana creatures you control can produce

Saheeli, Radiant Creator

Lightning Runner

Cast Ugin's Nexus by paying {5}.
Saheeli's first ability triggers, causing you to get {E}{E}{E}{E}.
At the beginning of your combat phase, Saheeli's second ability triggers, causing you to pay {E}{E}{E} to create a token copy of Ugin's Nexus that is a 5/5 artifact creature.
Put the nontoken Ugin's Nexus into exile due to the legend rule and its replacement effect, causing you to take an extra turn after this one.
Activate Karn's first loyalty ability by putting two loyalty counters on it.
At the beginning of the end step, Saheeli triggers, causing you to sacrifice the Ugin's Nexus token. The token put into exile due to its replacement effect, causing you to take an extra turn after this one.
Move to your first extra turn.
Activate Karn's second loyalty ability ability by removing two loyalty counters from it, putting Ugin's Nexus into your hand from exile.
Move to your second extra turn, and repeat from step 1.

Infinite turns

Lock

Karn, the Great Creator

Ugin's Nexus

Combos with "Aether Refinery"