Pox Plague by paying ({B} magic symbol) ({B} magic symbol) ({B} magic symbol) ({B} magic symbol) ({B} magic symbol) , causing each player to lose half their life, discard half their hand, and sacrifice half their permanents, rounded down. Ensure that you don't sacrifice
Archfiend of Despair.
At the beginning of your end step,
Archfiend of Despair triggers, causing each opponent to lose life equal to the life they've lost this turn.
Notes
Each opponent with an odd life total will have 1 life remaining. Each opponent with an even life total will have 0 life and lose the game.