Activate Aphetto Alchemist by tapping it, untapping itself.
When Aphetto Alchemist becomes untapped, Mesmeric Orb triggers, causing you to mill a card.
Repeat.

Infinite self-mill

Mesmeric Orb

Aphetto Alchemist

Tap Alphetto Alchemist to untap itself.
Mill 1 with Mesmeric Orb.
Repeat until you mill Nullpriest of Oblivion and Syr Konrad shuffling when you do not mill them using the Titan.
Cast and kick Nullpriest of Oblivion with Lurrus of the Dream-Den, bringing Syr Konrad to the battlefield.
Repeat Milling until you mill the Titan, dealing damage with Syr Konrad.

Infinite damage

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