Cast Marina Vendrell's Grimoire by paying {5}{U}.
When Marina Vendrell's Grimoire enters the battlefield, its first ability triggers, causing you to draw five cards.
Queza triggers five times.
Resolve the first Queza trigger, causing you to gain 1 life and an opponent to lose 1 life.
Marina Vendrell's Grimoire's second ability triggers, causing you to draw a card.
Queza triggers, causing you to gain 1 life and an opponent to lose 1 life.
Repeat from step 5.

Near-infinite lifegain

Near-infinite lifegain triggers

Infinite card draw

Near-infinite lifeloss

Infinite draw triggers

Marina Vendrell's Grimoire

Queza, Augur of Agonies

Discard a card.
Feast of Sanity triggers, dealing 1 damage to you and causing you to gain 1 life.
Marina Vendrell's Grimoire triggers twice.
Resolve the first trigger, causing you to draw a card.
Resolve the second trigger, causing you to discard a card.
Repeat from step 2.

Infinite self-discard triggers

Infinite rummaging

Feast of Sanity

Draw a card.
Niv-Mizzet triggers, dealing 1 damage to an opponent.
Exquisite Blood triggers, causing you to gain 1 life.
Marina Vendrell's Grimoire triggers, causing you to draw a card.
Repeat from step 2.

Near-infinite damage

Niv-Mizzet, the Firemind

Exquisite Blood

Niv-Mizzet, Parun

Attempt to draw a card. 
The draw will be replaced by Chains of Mephistopheles, instead causing you to discard Stinkweed Imp. Then, the draw will be replaced by Stinkweed Imp's dredge ability, causing you to mill cards and return Stinkweed Imp from your graveyard to your hand.
Dredger's Insight's first ability triggers, causing you to gain 1 life.
Marina Vendrell's Grimoire triggers, attempting to draw a card.
Repeat from step 2.

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