Cast Howl of the Horde by paying {2}{R} and sacrificing a creature with power two or greater.
Howl of the Horde's casualty ability triggers, creating two copies of it due to Twinning Staff.
Resolve each Howl of the Horde, causing you to copy the next instant or sorcery spell you cast six times.
Cast Prologue to Phyresis by paying {1}{U}.
Each Howl of the Horde triggers, copying Prologue to Phyresis a total of nine times due to Twinning Staff.
Resolve each Prologue to Phyresis, causing each opponent to get ten poison counters, and you to draw ten cards.
Each opponent loses the game due to having ten or more poison counters.

Each opponent loses the game

Anhelo, the Painter

Twinning Staff

Howl of the Horde

Prologue to Phyresis

Cast Howl of the Horde by paying {2}{R} and sacrificing a creature with power two or greater.
Howl of the Horde's casualty ability triggers, creating two copies of it due to Twinning Staff.
Resolve each Howl of the Horde, causing you to copy the next instant or sorcery spell you cast six times.
Cast Infectious Inquiry by paying {2}{B}.
Each Howl of the Horde triggers, copying Infectious Inquiry a total of nine times due to Twinning Staff.
Resolve each Infectious Inquiry, causing each opponent to get ten poison counters, and causing you to lose twenty life and draw twenty cards.
Each opponent loses the game due to having ten or more poison counters.

Infectious Inquiry

Cast Howl of the Horde by paying {2}{R} and sacrificing a creature with power two or greater.
Howl of the Horde's casualty ability triggers, creating two copies of it due to Twinning Staff.
Resolve each Howl of the Horde, causing you to copy the next instant or sorcery spell you cast six times.
Cast Vraska's Fall by paying {2}{B}.
Each Howl of the Horde triggers, copying Vraska's Fall a total of nine times due to Twinning Staff.
Resolve each Vraska's Fall, causing each opponent to get ten poison counters and sacrifice ten creatures and/or planeswalkers.
Each opponent loses the game due to having ten or more poison counters.

Vraska's Fall

Cast Howl of the Horde by paying {2}{R} and sacrificing a creature with power two or greater.
Howl of the Horde's casualty ability triggers, creating two copies of it due to Twinning Staff.
Resolve each Howl of the Horde, causing you to copy the next instant or sorcery spell you cast six times.
Cast Phyresis Outbreak by paying {2}{B}.
Each Howl of the Horde triggers, copying Phyresis Outbreak a total of nine times due to Twinning Staff.
Resolve each Phyresis Outbreak, causing each opponent to get ten poison counters.
Each opponent loses the game due to having ten or more poison counters.

Phyresis Outbreak

Cast Howl of the Horde by paying {2}{R}, copying the next instant or sorcery spell you cast.
Cast Reality Spasm by paying at least {3}{U}{U}, targeting at least three permanents and choosing the untap mode.
Howl of the Horde triggers, copying Reality Spasm, targeting at least three permanents.
Holding priority, activate at least two mana-producing permanents you control by tapping them, adding at least {1}{U}.
Activate Errant by paying {1}{U} and tapping it, copying the Reality Spasm copy, targeting Errant and at least two mana-producing permanents you control.
Resolve the copy of Reality Spasm from step 3, untapping Errant and at least two mana-producing permanents you control.
Repeat from step 4.

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