Cast Peer into the Abyss by paying {4}{B}{B}{B}, causing target opponent to draw half their library and lose half their life.
Activate Folio of Fancies's last ability by paying {2}{U} and tapping it, causing each opponent to mill cards equal to the number of cards in their hand.
During their draw step, the opponent targeted in step 1 loses the game due to drawing from an empty library.

Target opponent loses the game

Peer into the Abyss

Folio of Fancies

Activate Folio of Fancies's first ability by paying {2} and tapping it, causing each player to draw a card.
Smothering Tithe triggers, creating a Treasure token for each player who can't pay {2}.
Activate Mind Over Matter by discarding a card, untapping Folio of Fancies.
Activate both Treasure tokens by tapping and sacrificing those, adding two mana of any colors.
Repeat.

Infinite card draw

Near-infinite mill

Near-infinite colored mana

Near-infinite Treasure tokens

Smothering Tithe

Mind Over Matter

Activate Folio of Fancies's first ability by paying {4} and tapping it, causing each player to draw two cards.
Smothering Tithe triggers, creating a Treasure token for each player who can't pay {2}.
Activate Clock of Omens by tapping two Treasure tokens, untapping Folio of Fancies.
Activate four Treasure tokens by tapping and sacrificing those, adding four mana of any colors.
Repeat.

Clock of Omens

Activate Folio of Fancies by paying {2} and taping it, causing each player to draw a card.
Xyris triggers, creating a 1/1 Snake token for each card that opponent drew.
Activate Mind over Matter by discarding a card, untapping Folio of Fancies.
Activate Ashnod's Altar by sacrificing a 1/1 Snake token, adding {C}{C}.
Repeat.

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