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Combos that use a card with “Pithing” in the name, use a card with “Needle” in the name, and are legal in Commander.
Variants

Color Identity: B

Cards in combo:
Lethal Vapors
Pithing Needle
+1 other prerequisite
Results in combo:
Destroy all creatures that enter the battlefield
231 decks (EDHREC)

Color Identity: U

Cards in combo:
Aether Storm
Pithing Needle
+1 other prerequisite
Results in combo:
Players can't cast creature spells
72 decks (EDHREC)
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