Cast Peer into the Abyss by paying {4}{B}{B}{B}, causing an opponent to draw cards equal to half their library and causing them to lose half their life total, rounded up.
Nekusar triggers for each card drawn this way.
Resolve the first trigger, dealing 1 damage to the opponent.
If the opponent has 0 or less life, the opponent loses the game due to having zero or less life.
Repeat from step 3 for each remaining trigger and/or until the opponent loses the game.

Near-infinite card draw for target opponent

Near-infinite draw triggers for target opponent

Target opponent loses the game

Near-infinite damage to one opponent

Nekusar, the Mindrazer

Peer into the Abyss

Cast Windfall by paying {2}{U}, causing each player to discard their hand and then draw a number of cards equal to the greatest number of cards a player discarded this way.
Nekusar triggers for each card drawn this way, giving each opponent a poison counter for each card they drew.
Each opponent loses the game due to having ten or more poison counters

Each opponent loses the game

Windfall

Phyresis

Cast Echo of Eons by paying {4}{U}{U}, causing each player to discard their hands and draw seven cards.
Nekusar triggers for each card your opponents draw.
Resolve the first trigger, causing the opponent to get a poison counter.
If the opponent has ten or more poison counters, they lose the game as a state-based action.
Repeat from step 3 for each remaining trigger.
If needed, cast Echo of Eons from your graveyard for its flashback cost by paying {2}{U}, causing each player to discard their hands and draw seven cards.
Repeat from step 2.

Echo of Eons

Cast Worldfire by paying {6}{R}{R}{R}, exiling all permanents, all cards in all hands and graveyards, and setting each player's life total to one.
Cast Nekusar from the command zone by paying {2}{U}{B}{R} and commander tax, if applicable.
Whenever your opponent draw a card during their draw step, Nekusar causes them to draw an additional card and triggers twice.
Resolve the first Nekusar trigger, dealing 1 damage to the opponent.
The opponent loses the game due to having zero or less life.
Repeat from step 3 for each remaining opponent.

Exile all permanents

Near-infinite lifeloss

Exile all cards in hands and graveyards

Worldfire

Cast Enter the Infinite by paying {8}{U}{U}{U}{U}.
Hive Mind triggers, causing each opponent to copy Enter the Infinite.
Resolve the first opponent's Enter the Infinite, causing the opponent to draw their library, and then put a card on top of their library.
Nekusar triggers for each card they draw this way, dealing damage to the opponent equal to the number of cards they drew.
If the opponent has zero or less life, they lose the game.
Repeat step 3 for each other opponent.
If any opponents remain, resolve your Enter the Infinite, causing you to draw your library, and then put a card on top of your library.
Move to the first opponent's turn, causing them to draw two cards during their draw step due to Nekusar, and lose the game due to drawing from an empty library.
Repeat step 8 as necessary for each other opponent.

Infinite card draw for all players

Infinite draw triggers for all players

Near-infinite damage

Hive Mind

Enter the Infinite

Cast Harmless Offering by paying {2}{R}, giving control of Vilis to an opponent.
During that opponent's draw step, they draw a card.
Nekusar triggers, dealing 1 damage to the opponent.
Vilis triggers, causing the opponent to draw a card.
Repeat from step 3 until the opponent loses the game either due to drawing from an empty library, or from having 0 life.

Infinite card draw for target opponent

Infinite draw triggers for target opponent

Vilis, Broker of Blood

Harmless Offering

At the beginning of an opponent's upkeep, Assault Suit triggers, giving them control of Vilis.
During that player's next draw step, they draw a card.
Nekusar triggers, dealing 1 damage to that opponent.
Vilis triggers, causing the opponent to draw a card.
Repeat from step 3 until the opponent loses the game either due to drawing from an empty library or by having a life total of 0.
When the opponent loses the game, you regain control of Vilis.
Repeat from step 1 for each remaining opponent.

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