Cast Walk the Aeons by paying its mana cost, causing you to take an extra turn after this one.
Activate Dust Bowl by paying {3}, tapping it and sacrificing Mystic Sanctuary, destroying a nonbasic land.
Play Mystic Sanctuary from your graveyard.
When Mystic Sanctuary enters untapped, it triggers, putting Walk the Aeons from your graveyard onto the top of your library.
Move to your next turn, drawing Walk the Aeons during your draw step.
Repeat.

Skip your draw steps

Near-infinite extra turns

Mystic Sanctuary

Dust Bowl

Szarel, Genesis Shepherd

Walk the Aeons

Cast Walk the Aeons by paying {4}{U}{U}, sacrificing Mystic Sanctuary and two other Islands, causing you to take an extra turn after this one and returning Walk the Aeons to your hand.
Play any Island except Mystic Sanctuary from your graveyard.
When the land enters the battlefield, Aesi triggers, allowing you to draw a card.
Move to your next turn.
Cast Walk the Aeons by paying {4}{U}{U}, causing you to take an extra turn after this one.
Play any Island except Mystic Sanctuary from your graveyard.
When the land enters the battlefield, Aesi triggers, allowing you to draw a card.
Play Mystic Sanctuary from your graveyard.
When Mystic Sanctuary enters the battlefield, it and Aesi trigger.
Resolve the Mystic Sanctuary trigger, putting Walk the Aeons on top of your library from your graveyard.
Resolve the Aesi trigger, causing you to draw Walk the Aeons from the top of your library.
Move to your next turn.
Repeat.

Infinite turns

Lock

Aesi, Tyrant of Gyre Strait

Cast Enter the Unknown either from your hand by paying {G} or from the top of your library by paying 1 life, causing a creature you control to explore and allowing you to play an additional land this turn.
Play Mystic Sanctuary either from your hand or graveyard.
When Mystic Sanctuary enters the battlefield untapped, it triggers, putting Enter the Unknown from your graveyard onto the top of your library.
Activate Mystic Sanctuary by tapping it, adding {U}.
Activate Zuran Orb by sacrificing Mystic Sanctuary, causing you to gain 2 life.
Repeat.

Infinite lifegain triggers

Infinite lifegain

Infinite storm count

Infinite blue mana

Infinite magecraft triggers

Infinite landfall triggers

Infinite +1/+1 counters on creatures you control

Enter the Unknown

Bolas's Citadel

Zuran Orb

Cast Enter the Unknown either from your hand by paying {G} or from the top of your library by paying 1 life, causing a creature you control to explore and allowing you to play an additional land this turn.
Play Mystic Sanctuary either from your hand or graveyard.
When Mystic Sanctuary enters the battlefield untapped, it triggers, putting Enter the Unknown from your graveyard onto the top of your library.
Activate Mystic Sanctuary by tapping it, adding {U}.
Activate Overgrown Estate by sacrificing Mystic Sanctuary, causing you to gain 3 life.
Repeat.

Overgrown Estate

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