Activate Wall of Blood by paying life.
Repeat step 1 until you have 0 life.
Cast Mister Negative by paying {5}{W}{B} plus commander tax if applicable.
When Mister Negative enters, it triggers, swapping your life total with an opponent's.
The opponent loses the game due to having 0 life.

Near-infinite lifeloss for target opponent

Target opponent loses the game

Mister Negative

Wall of Blood

Phyrexian Unlife

Activate Saffi by sacrificing it, targeting Mistmoon Griffin.
Activate Bloodthrone Vampire by sacrificing Mistmoon Griffin.
When Mistmoon Griffin dies, it and Saffi trigger.
Resolve the Saffi trigger, returning Mistmoon Griffin from your graveyard to the battlefield.
Resolve the Mistmoon Griffin trigger, failing to exile it as it is not in your graveyard and then returning Saffi from your graveyard to the battlefield.
Resolve the Bloodthrone Vampire ability.
Repeat.

Infinite creature ETB

Infinite creature LTB

Infinite creature sacrifice triggers

Infinite death triggers

Infinitely large creature until end of turn

Saffi Eriksdotter

Mistmoon Griffin

Bloodthrone Vampire

Activate Marina by tapping it, unlocking Mirror Room.
Mirror Room triggers twice due to Fractured Realm, creating two token copies of Aphetto Alchemist.
Activate one of the Aphetto Alchemist tokens by tapping it, untapping Marina.
Activate Marina by tapping it, locking Mirror Room.
Activate the other Aphetto Alchemist token by tapping it, untapping Marina.
Repeat.

Infinite tapped creature tokens

Marina Vendrell

Mirror Room // Fractured Realm

Purphoros, Bronze-Blooded

Aphetto Alchemist

Activate Accomplished Alchemist by tapping it, adding an amount of {G}.
Activate Temur Sabertooth by paying {1}{G}, returning Accomplished Alchemist from the battlefield to your hand.
Cast Accomplished Alchemist by paying its mana cost.
Repeat.

Infinite blinking

Infinite colored mana

Infinite storm count

Temur Sabertooth

Accomplished Alchemist

Activate Bloodflow Connoisseur by sacrificing Granite Witness.
When Granite Witness dies, Yedora triggers, returning Granite Witness from your graveyard to the battlefield face-down as a Forest land.
Resolve the Bloodflow Connoisseur ability, putting a +1/+1 counter on it.
Activate Granite Witness by tapping it, adding {G}.
Activate Skirk Alarmist by tapping it, turning Granite Witness face-up.
Granite Witness triggers, untapping Skirk Alarmist.
Repeat.

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