Cast Ad Nauseam by paying {3}{B}{B}.
Resolve Ad Nauseam, revealing the top card of your library, putting that card into your hand and losing no life due to Teferi's Protection
Repeat the process in step 2 as many times as desired.

Infinite card draw

Ad Nauseam

Teferi's Protection

Cast Ad Nauseam by paying {3}{B}{B}.
Resolve Ad Nauseam, revealing the top card of your library, putting that card into your hand and losing life equal to that card's mana value.
Repeat the process in step 2 as many times as desired.

Phyrexian Unlife

Platinum Angel

Cast Angel's Grace by paying {W}, preventing you from losing the game this turn.
Cast Ad Nauseam by paying {3}{B}{B}.
Resolve Ad Nauseam, revealing the top card of your library, putting that card into your hand and losing life equal to that card's mana value.
Repeat the process in step 3 until you revealed Sicken Dreams and cards in your hand are greater than opponent life total.
Cast Sickening Dreams by paying {1}{B} and discarding cards equal to amount of opponent life total, dealing damage to each creature and each players.

Near-infinite damage

Angel's Grace

Sickening Dreams

At the beginning of your upkeep, cast Angel's Grace by paying {W}, preventing you from losing the game this turn.
Cast Ad Nauseam by paying {3}{B}{B}.
Resolve Ad Nauseam, revealing the top card of your library, putting that card into your hand and losing life equal to that card's mana value.
Repeat the process in step 3 until you have an empty library.
On your draw step, Laboratory Maniac triggers, winning you the game.

Win the game

Laboratory Maniac

Cast Angel's Grace by paying {W}, preventing you from losing the game this turn.
Cast Ad Nauseam by paying {3}{B}{B}.
Resolve Ad Nauseam, revealing the top card of your library, putting that card into your hand and losing life equal to that card's mana value.
Repeat the process in step 3 until you have an empty library.
If Jace is in your hand, cast it by paying {1}{U}{U}{U}.
Activate Jace's first loyalty ability by putting a loyalty counter on it, causing target player to mill two cards and you to win the game due to drawing from an empty library.

Jace, Wielder of Mysteries

Cloudsteel Kirin

During the end step prior to your turn, cast Ad Nauseam by paying {3}{B}{B}.
Resolve Ad Nauseam, putting the top card of your library into your hand and losing life equal to that card's mana value.
Repeat the process in step 2 until you have thirteen cards in your hand.
At the beginning of your upkeep, Triskaidekaphile triggers, causing you to win the game.

Win the game at the beginning of your next upkeep

Triskaidekaphile

Gideon of the Trials

Lich

Soul Echo

Cast Angel's Grace by paying {W}, preventing you from losing the game this turn.
Cast Ad Nauseum by paying {3}{B}{B}, putting your entire library in your hand and losing life equal to the total converted mana cost of those cards.
Activate Skirge Familiar many times by discarding your entire hand, adding {B} for each card discarded.
Actviate Pestilence many times by paying {B} each time, dealing 1 damage to each creature and each player each time.

Near-infinite black mana

Skirge Familiar

Pestilence

Cast Angel's Grace by paying {W}, preventing you from losing the game this turn.
Cast Ad Nauseam by paying {3}{B}{B}, putting your entire library into your hand and losing life equal to each card's mana value.
Activate Cadaverous Bloom by exiling a card from your hand, adding {B}{B}.
Activate Pestilence twice by paying {B}{B}, dealing 2 damage to each creature and each player.
Your life total is instead set to one due to Angel's Grace.
Repeat from step 3.

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