Cast Wheel of Misfortune by paying {2}{R}.
Judith triggers, giving Wheel of Misfortune deathtouch and lifelink.
Resolve Wheel of Misfortune, choosing an arbitrarily large number.
If you didn't choose the largest number, Wheel of Misfortune deals damage equal to the highest number chosen to each player that chose it, causing those players to lose the game due to having 0 or less life.
If you chose the largest number, Wheel of Misfortune deals that much damage to you and causes you to gain twice that much life.

Near-infinite lifegain

Judith, Carnage Connoisseur

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