Cast Pox Plague by paying {B}{B}{B}{B}{B}, causing you to lose half your life, and each player to discard half their hand and sacrifice half their permanents, rounded down. Each opponent will lose half their life, rounded down, and then doubled due to Bloodletter of Aclazotz.

Near-infinite lifeloss for all players

Pox Plague

Bloodletter of Aclazotz

Cast Pox Plague by paying {B}{B}{B}{B}{B}, causing each player to lose half their life, discard half their hand, and sacrifice half their permanents, rounded down. Ensure that you don't sacrifice Wound Reflection.
At the beginning of your end step, Wound Reflection triggers, causing each opponent to lose life equal to the life they've lost this turn.

Wound Reflection

Cast Pox Plague by paying {B}{B}{B}{B}{B}, causing each player to lose half their life, discard half their hand, and sacrifice half their permanents, rounded down. Ensure that you don't sacrifice Archfiend of Despair.
At the beginning of your end step, Archfiend of Despair triggers, causing each opponent to lose life equal to the life they've lost this turn.

Archfiend of Despair

Cast Pox Plague by paying {B}{B}{B}{B}{B}, causing each player to lose half their life, discard half their hand, and sacrifice half their permanents, rounded down. Ensure that you don't sacrifice Warlock Class.
At the beginning of your end step, Warlock Class triggers, causing each opponent to lose life equal to the life they've lost this turn.

Warlock Class

Cast Pox Plague by paying {B}{B}{B}{B}{B}, causing each player to lose half their life, discard half their hand, and sacrifice half their permanents, rounded down. Ensure that you don't sacrifice Astarion.
At the beginning of your end step, Astarion triggers, causing an opponent to lose life equal to the life they've lost this turn.

Astarion, the Decadent

Cast Pox Plague by paying {B}{B}{B}{B}{B}, causing each player to lose half their life, discard half their hand, and sacrifice half their permanents, rounded down. Ensure that you don't sacrifice Blitzwing
At the beginning of your end step, Blitzwing triggers, causing an opponent to lose life equal to the life they've lost this turn.

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