Cast Storm King's Thunder by paying {R}{R}{R} plus an additional {1} for every twenty life your opponents collectively have, copying the next instant or sorcery spell you cast that many times.
Cast Scheming Symmetry by paying {B}.
Storm King's Thunder triggers, copying Scheming Symmetry at least once.
Resolve a Scheming Symmetry, causing two opponents to search their library for a card, and then shuffle their libraries and put the card on top of it.
Ob Nixilis triggers for each opponent who searched their library, causing them to lose ten life.
Repeat from step 4 for each remaining Scheming Symmetry.

Each opponent loses the game

Near-infinite lifeloss

Ob Nixilis, Unshackled

Storm King's Thunder

Scheming Symmetry

Cast Micromancer by paying {3}{U}.
Micromancer enters the battlefield and triggers, searching your library for Dark Ritual and putting it into your hand.
Cast Dark Ritual by paying {B}.
Displacer Kitten triggers, blinking Micromancer.
Micromancer triggers, searching your library for Scheming Symmetry and putting it into your hand.
Dark Ritual resolves, adding {B}{B}{B} and going to the bottom of your library.
Cast Scheming Symmetry by paying {B}, targeting any two players.
Displacer Kitten triggers, blinking Micromancer.
Micromancer triggers, searching your library for Dark Ritual and putting it into your hand.
Scheming Symmetry triggers, exiling a card from each targeted opponent's library due to Opposition Agent's effect, and going to the bottom of your library.
Repeat from step 3.

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