Cause one or more opponents to lose life.
Mindcrank triggers once for each life loss event, causing that player to mill cards equal to the amount of life lost.
Bloodchief Ascension triggers once for each card milled, causing that player to lose 2 life and you to gain 2 life for each trigger.
Repeat from step 2.

Infinite mill

Near-infinite lifegain

Near-infinite lifegain triggers

Near-infinite lifeloss

Bloodchief Ascension

Mindcrank

Cause one or more opponents to lose life.
The Master of Lake-town triggers once for each life loss event, causing that player to mill cards equal to the amount of life lost.
Bloodchief Ascension triggers once for each card milled, causing that player to lose 2 life and you to gain 2 life for each trigger.
Repeat from step 2.

The Master of Lake-town

If an opponent would draw a card, pay 2 life to put that card into their graveyard instead.
Bloodchief Ascension triggers, causing that player to lose 2 life and you to gain 2 life.

Your opponents mill cards instead of drawing them

Lock

Zur's Weirding

Activate Hair-Strung Koto by tapping Famished Paladin, causing an opponent to mill a card.
Bloodchief Ascension triggers, causing the opponent to lose 2 life and you to gain two life.
Famished Paladin triggers, untapping itself.
Repeat.

Hair-Strung Koto

Famished Paladin

Activate Hair-Strung Koto by tapping Lurking Roper, causing an opponent to mill a card.
Bloodchief Ascension triggers, causing the opponent to lose 2 life and you to gain two life.
Lurking Roper triggers, untapping itself.
Repeat.

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