Nekusar, the Mindrazer | Windfall | Triumph of the Hordes

Cards

A player has a number of cards in hand equal to ten minus the fewest number of infect counters among your opponents.

({4} magic symbol) ({G} magic symbol) ({G} magic symbol) ({U} magic symbol) available.

Cast
Triumph of the Hordes by paying ({2} magic symbol) ({G} magic symbol) ({G} magic symbol) , giving creatures you control +1/+1 and infect until end of turn.
Cast
Windfall by paying ({2} magic symbol) ({U} magic symbol) , causing each player to discard their hands, and draw cards equal to the greatest amount of cards discarded this way.
Nekusar triggers for each card your opponents draw.
Resolve the first trigger, causing the opponent to get a poison counter.
If the opponent has ten or more poison counters, they lose the game as a state-based action.
Repeat from step 4 for each remaining trigger, and/or until each opponent has lost the game.