Razorkin Needlehead and Corrupted Conscience on the battlefield.
A player has a number of cards in hand equal to ten minus the fewest number of infect counters among your opponents.
Corrupted Conscience attached to Razorkin Needlehead.
({2} magic symbol) ({U} magic symbol) available.
Steps
Cast Windfall by paying ({2} magic symbol) ({U} magic symbol) , causing each player to discard their hands, and draw cards equal to the greatest amount of cards discarded this way.
Razorkin Needlehead triggers for each card your opponents draw.
Resolve the first trigger, causing the opponent to get a poison counter.
If the opponent has ten or more poison counters, they lose the game as a state-based action.
Repeat from step 3 for each remaining trigger, and/or until each opponent has lost the game.