Laboratory Maniac in hand or in your graveyard or in your library.
Stunning Reversal in exile (Stunning Reversal exiled by Elite Arcanist).
Transcendence in hand.
Elite Arcanist and Mind Over Matter on the battlefield.
Elite Arcanist does not have summoning sickness.
You have at least 20 life.
You control a land that can tap to add ({B} magic symbol) .
NOTE: This combo could fail if your library size is not a multiple of seven and a combo piece is near the bottom, but this risk is easily minimized mid-combo by tutors or library size manipulation.
In response, pay ({4} magic symbol) and tap Elite Arcanist to activate it, casting and resolving a copy of Stunning Reversal without paying its mana cost.
Resolve the Transcendence ability modified by Stunning Reversal's replacement effect, drawing seven cards and lowering your life total to 1.
Transcendence's last ability triggers.
In response, discard a card to activate Mind Over Matter, untapping Elite Arcanist.
Discard a card to activate Mind Over Matter again, untapping a land you control.
Tap that land to add ({1} magic symbol) .
Repeat steps 7 and 8 at least four additional times, resulting in at least ({5} magic symbol) available.
Resolve Transcendence's ability, gaining at least 38 life.
Repeat steps 2 through 10 until there are six or fewer cards remaining in your library, Laboratory Maniac is in your graveyard, and Betrayal of Flesh is in your hand.
Transcendence's second ability triggers.
In response, pay ({5} magic symbol) ({B} magic symbol) to cast Betrayal of Flesh, returning Laboratory Maniac from your graveyard to the battlefield.
Pay ({4} magic symbol) and tap Elite Arcanist to activate it, casting and resolving a copy of Stunning Reversal without paying its mana cost.
Resolve the Transcendence ability modified by Stunning Reversal's and Laboratory Maniac's replacement effects, winning the game.
Results
Near-infinite card draw.
Near-infinite looting.
Near-infinite self-discard triggers.
Near-infinite untap of artifacts, creatures, or lands.