Jace in hand or on the battlefield or in your library.
Ad Nauseam and
Angel's Grace in hand.
Mana Needed
({3} magic symbol) ({W} magic symbol) ({B} magic symbol) ({B} magic symbol) plus an additional ({1} magic symbol) ({U} magic symbol) ({U} magic symbol) ({U} magic symbol) available if
Jace is not on the battlefield available.
Steps
Cast
Angel's Grace by paying ({W} magic symbol) , preventing you from losing the game this turn.
Cast
Ad Nauseam by paying ({3} magic symbol) ({B} magic symbol) ({B} magic symbol) .
Resolve
Ad Nauseam, revealing the top card of your library, putting that card into your hand and losing life equal to that card's mana value.
Repeat the process in step 3 until you have an empty library.
If
Jace is in your hand, cast it by paying ({1} magic symbol) ({U} magic symbol) ({U} magic symbol) ({U} magic symbol) .
Activate
Jace's first loyalty ability by putting a loyalty counter on it, causing target player to mill two cards and you to win the game due to drawing from an empty library.