With Ob Nixilis, the Hate-Twisted on the battlefield, cast Peer into the Abyss targeting an opponent.
Peer into the Abyss would resolve (with card draw and life loss rounded up in instances of odd number of cards or life), and then the static ability on Ob Nixilis, the Hate-Twisted dealing damage for each card drawn.

Target player loses the game

Ob Nixilis, the Hate-Twisted

Peer into the Abyss

Cast Harmless Offering by paying {2}{R}, giving control of Demonic Pact to an opponent.
At the beginning of the opponent's upkeep, Demonic Pact triggers, causing them to select the fourth mode and lose the game.

Target opponent loses the game at the beginning of their next upkeep

Demonic Pact

Harmless Offering

Activate Vilis by paying {B} and 2 life, targeting any creature.
Vilis triggers, causing you to draw two cards.
Curse of Fool's Wisdom triggers twice.
Resolve a Curse of Fool's Wisdom trigger, causing you to gain 2 life and lose 2 life.
Repeat from step 2.

Infinite card draw

Infinite draw triggers

Near-infinite lifegain triggers

Vilis, Broker of Blood

Curse of Fool's Wisdom

Cast Harmless Offering by paying {2}{R}, giving an opponent control of Vilis.
During that player's next draw step, they draw a card.
Underworld Dreams triggers, dealing 1 damage to that opponent.
Vilis triggers, causing the opponent to draw a card.
Repeat from step 3.

Infinite card draw for target opponent

Infinite draw triggers for target opponent

Near-infinite damage to one opponent

Underworld Dreams

Cast Harmless Offering by paying {2}{R}, giving control of Vilis to an opponent.
During that opponent's draw step, they draw a card.
Razorkin Needlehead triggers, dealing 1 damage to the opponent.
Vilis triggers, causing the opponent to draw a card.
Repeat from step 3 until the opponent loses the game either due to drawing from an empty library, or from having 0 life.

Target opponent loses the game

Razorkin Needlehead

Cast Harmless Offering by paying {2}{R}, giving an opponent control of Vilis.
During that player's next draw step, they draw a card.
Kederekt Parasite triggers, dealing 1 damage to that opponent.
Vilis triggers, causing the opponent to draw a card.
Repeat from step 3.

Kederekt Parasite

Cast Harmless Offering by paying {2}{R}, giving an opponent control of Vilis.
During that player's next draw step, they draw a card.
Fate Unraveler triggers, dealing 1 damage to that opponent.
Vilis triggers, causing the opponent to draw a card.
Repeat from step 3.

Fate Unraveler

At the beginning of an opponent's upkeep, Assault Suit triggers, giving them control of Vilis.
During that player's next draw step, they draw a card.
Ob Nixilis triggers, dealing 1 damage to that opponent.
Vilis triggers, causing the opponent to draw a card.
Repeat from step 3 until the opponent loses the game either due to drawing from an empty library or by having a life total of 0.
When the opponent loses the game, you regain control of Vilis.
Repeat from step 1 for each remaining opponent.

Each opponent loses the game

Infinite card draw for each opponent

Infinite draw triggers for each opponent

Near-infinite damage

Assault Suit

Cast Harmless Offering by paying {2}{R}, giving control of Vilis to an opponent.
During that opponent's draw step, they draw a card.
Nekusar triggers, dealing 1 damage to the opponent.
Vilis triggers, causing the opponent to draw a card.
Repeat from step 3 until the opponent loses the game either due to drawing from an empty library, or from having 0 life.

Nekusar, the Mindrazer

Cast Donate by paying {2}{U}, giving an opponent control of Vilis.
During that player's next draw step, they draw a card.
Ob Nixilis triggers, dealing 1 damage to that opponent.
Vilis triggers, causing the opponent to draw a card.
Repeat from step 3.

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