Attempt to deal any amount of damage to Phyrexian Vindicator.
Phyrexian Vindicator prevents the damage and triggers, dealing that much damage to any target.
Guilty Conscience triggers, attempting to deal that much damage to Phyrexian Vindicator.
Repeat from step 2.

Infinite damage

Guilty Conscience

Phyrexian Vindicator

Cast Star of Extinction by paying {5}{R}{R}, dealing 20 damage to each creature and planeswalker and destroying a land.
Each Sliver you control triggers, dealing 20 damage to any target for each trigger.

Near-infinite damage

Spiteful Sliver

Star of Extinction

Cause Spiteful Sliver to take damage by any method.
Spiteful Sliver triggers, dealing damage to an opponent.
Guilty Conscience triggers, dealing damage to Spiteful Sliver.
Repeat from step 2.

Infinite damage to one opponent

Card that gives indestructible

Declare any creature as an attacker. Dawnsire triggers, dealing 100 damage to  Spiteful Sliver.
Spiteful Sliver triggers, dealing 100 damage to target player.

Near-infinite damage to target player

Dawnsire, Sunstar Dreadnought

Cast Fire Covenant by {1}{B}{R} and paying an amount of life equal to an opponent's life total, dealing that much damage to Spiteful Sliver.
Spiteful Sliver triggers, dealing that much damage to the opponent.

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