Aetherflux Reservoir | Cloudstone Curio | Defiler of Instinct

Cards

Your life total is at least 5.
You have a red nonartifact permanent card in hand with mana cost ({R} magic symbol) .
You control a nontoken nonartifact red permanent with mana cost ({R} magic symbol) that shares a card type with the card in hand.

Cast the red permanent card in your hand by paying 2 life.
Defiler of Instinct and
Aetherflux Reservoir triggers.
Resolve the
Defiler of Instinct trigger, dealing 1 damage to any target.
Resolve the
Aetherflux Reservoir trigger, causing you to gain 1 life for each spell you've cast before it this turn.
The red permanent enters the battlefield, triggering
Cloudstone Curio, returning another nontoken nonartifact red permanent with mana cost ({R} magic symbol) from the battlefield to your hand.
Repeat.