Minsc & Boo and Soul of Eternity on the battlefield.
Minsc & Boo has at least two loyalty counters on it.
Your life total is higher than or equal to an opponent's.
Steps
Activate Minsc & Boo's second loyalty ability by removing two loyalty counters from it, sacrificing Soul of Eternity and dealing damage equal to Soul of Eternity's power to target opponent with a life total equal to or less than your life total.
The opponent loses the game due to having 0 or less life.