Marina Vendrell's Grimoire | Queza, Augur of Agonies

Cards

Cast
Marina Vendrell's Grimoire by paying ({5} magic symbol) ({U} magic symbol) .
When
Marina Vendrell's Grimoire enters the battlefield, its first ability triggers, causing you to draw five cards.
Queza triggers five times.
Resolve the first
Queza trigger, causing you to gain 1 life and an opponent to lose 1 life.
Marina Vendrell's Grimoire's second ability triggers, causing you to draw a card.
Queza triggers, causing you to gain 1 life and an opponent to lose 1 life.
Repeat from step 5.

This combo will result in you eventually drawing from an empty library, thus losing the game. It is highly recommended to have a way to stop the combo at instant speed or to otherwise stop yourself from losing the game.