Cast Shrieking Drake by paying 2 life.
Defiler of Dreams and Aetherflux Reservoir trigger.
Resolve the Aetherflux Reservoir trigger, causing you to gain 1 life for each spell you've cast this turn.
Resolve the Defiler of Dreams trigger, causing you to draw a card.
Shrieking Drake enters the battlefield, returning itself from the battlefield to your hand.
Repeat until you have an empty library.
Activate Aetherflux Reservoir by paying fifty life, dealing fifty damage to any target.
Repeat step 7 as many times as desired.

Infinite card draw

Infinite draw triggers

Near-infinite damage

Near-infinite creature ETB

Near-infinite lifegain

Near-infinite lifegain triggers

Near-infinite creature LTB

Defiler of Dreams

Shrieking Drake

Aetherflux Reservoir

Cast the blue permanent card in your hand by paying 2 life.
Defiler of Dreams and Aetherflux Reservoir triggers.
Resolve the Defiler of Dreams trigger, causing you to draw a card.
Resolve the Aetherflux Reservoir trigger, causing you to gain 1 life for each spell you've cast before it this turn.
The blue permanent enters the battlefield, triggering Cloudstone Curio, returning another nontoken nonartifact blue permanent with mana cost {U} from the battlefield to your hand.
Repeat until you have an empty library.
Activate Aetherflux Reservoir by paying fifty life, dealing fifty damage to any target.
Repeat step 7 as many times as desired.

Near-infinite storm count

Cloudstone Curio

Cast Shrieking Drake by paying 2 life.
Defiler of Dreams triggers, causing you to draw a card.
Sheoldred's second ability triggers, causing you to gain 2 life.
When Shrieking Drake enters the battlefield, it triggers, returning itself to your hand.
Repeat.

Sheoldred, the Apocalypse

Activate an artifact, creature, or land by tapping it, adding at least {U}.
Cast Shrieking Drake by paying {U}.
Defiler of Dreams triggers, causing you to draw a card.
Resolve Shrieking Drake, causing it to enter the battlefield, returning itself from the battlefield to your hand.
Activate Mind over Matter by discarding a card, untapping the mana-producing permanent from step 1.
Repeat.

Infinite looting

Infinite self-discard triggers

Mind Over Matter

Cast Ugin's Conjurant, choosing to have X=2, but paying {0} due to Ezzaroot Channeler.
Bounteous Kirin and Kiri-Onna trigger.
Resolve the Bounteous Kirin trigger, causing you to gain two life.
Resolve the Kiri-Onna trigger, returning it to your hand from the battlefield.
Cast Kiri-Onna by paying two life due to Ezzaroot Channeler and Defiler of Dreams.
Defiler of Dreams triggers, causing you to draw a card.
When Kiri-Onna enters the battlefield, it triggers, returning Ugin's Conjurant to your hand from the battlefield.
Repeat.
Once you have drawn your library, you may cast Ugin's Conjurant with X equaling the amount of life you gained this turn to have it enter the battlefield with a large amount of +1/+1 counters, and to gain that much life due to Bounteous Kirin.

Combos with "Defiler of Dreams"